As we learn about the technique of Gene Therapy this week, we find a tchnology and approach with which promise but little recorded success. One major porblem has been the specificity with which the genes can be delivered to their intended target cells - aer all it is only usually in a subset of cells where a particular gene of interest is active.
Reaserch this week is honing in on how to better tailor viruses as vehicles for gene therapy, and avoiding their hitting the wrong target - in this case, the liver. The adenovirus shown above is the vector of study and they are finding it is through the hexon protein (see graphic) that this virus gains access to the liver - the thought now is how to disrupt that. Full article is HERE
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